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This is a dosing consideration that the calculator cannot address, because it involves pharmacokinetic interactions beyond simple concentration math

Available from: nutrition-surveillance/health-nutrition-surveys/canadian-health-measures-survey/folate-nutrition-biomarkers-cycle-1-canadian-health-measures-survey-food- nutrition-surveillance-health-canada.html Wilson RD, Audibert F, Brock JA, Carroll J, Cartier L, Gagnon A, et al

The analysis typically considers four factors: the physical and chemical characterization of the substance, any safety issues raised by using the substance in compounding, the available evidence of effectiveness for the use, and historical use of the substance in compounding, including the medical condition being treated and any references in the medical literature